Tendulkar retired from international cricket last week after playing his 200th Test against West Indies in Mumbai.
Next month, India will play their first Test series without Tendulkar in 24 years. Tendulkar, who made his international debut in 1989 against Pakistan, has been an integral part of Team India for over two decades.
India will play two Tests against South Africa in December for which the team will welcome a new batsman to occupy Tendulkar's number four slot.
"Sachin has had a great and long innings in the game. But I suppose this is part of life, unfortunately. We will miss him a lot. Honestly speaking, it will feel quite strange playing against India at home without Sachin," Kallis told "The Times of India" on Wednesday.
Kallis, however, is not ready to admit that the series will lose its sheen without the Master Blaster. According to the senior all-rounder, there are other players in the Indian team who will make it a good series.
"I am sure that Sachin will be the first one to say that the game is always bigger than any individual. I firmly believe that the game will continue to be glamorous with new gladiators in the ring," he said.
Kallis said it will be a "great" series between the sides. "I'm sure it will be a great series between two good sides. India played here last in 2010 and I'm looking forward to the series again and I can assure you a great clash."
Kallis said he is not chasing Tendulkar's Test record of 51 centuries. "This is not on my mind and let me tell you it's certainly not something what drives me," he said.
India will begin with three ODIs from December 5 against South Africa and later play two Tests (from December 18).