Paul Downton, the Managing Director of England Cricket, unveiled Moores as head coach at Lord's Cricket Ground today. Moores replaces Andy Flower.
The 51-year-old Moores, in April 2007 succeeded Duncan Fletcher. However, he was sacked from the post in 2009 after he fell out with Kevin Pietersen. Moores has been head coach at Lancashire since February 2009.
Downton said: "Peter has a great reputation around the world as an outstanding coach and he will return to the role as England head coach with a great deal more experience and understanding of the challenges that the role presents."
"There is no doubt that he is the leading English coach of his generation and I believe that this is his time," Downton added.
On his return, Moores said: "I am very excited about the prospect of returning to a role I have done before and to building a strong relationship with Alastair Cook and the rest of the players and staff. In any time of change there comes opportunity and this is one I can't wait to get stuck into."
Downton was joined on the interview panel by England and Wales Cricket Board (ECB) Head of Elite Coach Development Gordon Lord and ECB Chief Executive David Collier, who said: "Paul Downton conducted a thorough and far-reaching recruitment process.
"He has canvassed opinion worldwide resulting in the recommendation of Peter Moores. The Board unanimously endorsed the recommendation and have every confidence in the choice of Peter. We wish Peter every success in the future.
"I would like to thank all the other candidates who made up what was an extremely impressive shortlist and in particular I would like to acknowledge the work of Ashley Giles, who has made a major contribution to cricket in England and Wales."